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Finding the Best Medication For ADHD The most commonly prescribed medication for ADHD is stimulants. Amphetamines and methylphenidates are among the most commonly prescribed stimulants. Short-acting stimulants are effective within less than an hour and should be taken several times a day. Long-acting stimulants last for up to 16 hours, and are usually taken only once a day. Your doctor may prescribe antidepressants, or other types of medications "off-label" to treat ADHD symptoms. These medications