https://www.selleckchem.com/pr....oducts/shp099-dihydr
RESULTS We observed that HtrA4 significantly up-regulated IGFBP3, SERPINE1 and SERPINB2, which all promote senescence. IGFBP-3 protein was also significantly elevated in the media of HtrA4-treated HUVECs. Conversely, a number of genes including CDKN2C, PCNA, CALR, CHEK2 and NOX4 were downregulated by HtrA4. Many of these genes also showed a similar trend of change in EPCs following HtrA4 treatment. DISCUSSION Elevation of placenta-derived HtrA4 in PE alters the expression of endothelial genes to promote cellular senescenc
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