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Background ACE angioedema has not been characterized in comparison with angioedema from other causes in acute hospitalized patients. Methods We retrospectively compared ACE-angioedema and non-ACE angioedema patients from January 2013 to May 2017. Results Of 855 cases screened, 575 met the inclusion criteria of angioedema diagnosis and an electronic medical record. Of these, 297 (51.7%) had ACE angioedema and 278 had angioedema from other causes, of these 31 who were taking an ACE inhibitor that was not considered to be the cause of angi