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Previous reviews on Myo10 include Divito MM, Cheney RE, (Myosins a superfamily of molecular motors chapter 14 MYOSIN X. In Proteins and cell regulation, vol 7. Springer, Dordrecht, 2008) and Kerber ML, Cheney RE (J Cell Sci 1243733-3741).Class IX myosins are simultaneously motor and signaling molecules. In addition to myosin class-specific functions of the tail region, they feature unique motor properties. Within their motor region they contain a long insertion with a calmodulin- and a F-actin-binding site. The rate-limiting step in the