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The Most Effective ADHD Medication For Adults Stimulants are the most effective medication for adults with ADHD. They help regulate levels of two chemical signals in the brain that control the attention. Strattera (atomoxetine) is the most effective treatment for adhd available for adults. It is available as capsules that can be taken with food or without food. It is suitable for the majority of people. It lasts longer than stimulants with an action time that is shorter like amphetamine or methylphenidate. 1. Strattera Strattera (atomoxetine) is a n