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BACKGROUND People living with HIV who were diagnosed before highly active antiretroviral therapy became available in 1996 and who survived at least 15 years after HIV diagnosis, termed long-term survivors (LTS), form a particularly vulnerable population. We study social, clinical and mental factors of LTS in the Swiss HIV Cohort Study, with a particular focus on people who inject drugs (PWID). METHODS We quantified differences between PWID LTS and men who have sex with men (MSM) and heterosexual (HET) LTS. Using phylogenetic methods, we