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NEW FINDINGS What is the central question of this study? Astronauts onboard the International Space Station (ISS) perform daily exercises designed to prevent muscle atrophy and bone demineralisation. The present study assessed the effect of resistive exercise performed by subjects while exposed to the same level of hypercapnia as on the ISS on intraocular pressure (IOP). What is the main finding and its importance? The static exercise-induced IOP elevation in intraocular pressure during 6° prone head down tilt (simulating the headward shi
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