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Nonetheless, it reveals high poisoning also on typical cells which is maybe not particular for isotype βIII. In this framework, the search for colchicine types is a matter of great importance in disease research. In this research, homology modeling techniques, molecular docking, and molecular characteristics simulations are used to define the discussion between 55 new promising colchicine types and tubulin isotype βIII. These substances were screened and ranked predicated on their binding