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The estimated median daily intakes of total methylsiloxanes through street dust were 0.037 and 0.476 ng/kg-bw/d for adults and children, respectively, under high-exposure scenarios. More research is needed to characterize the occurrence of methylsiloxane in various exposure sources and the associated adverse effects on human health.The molecular mechanisms of air pollution-associated adverse cardiovascular effects remain largely unknown. In the present study, we investigated the impacts of ambient air pollution on vascular function and the