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Signatures with a high amount of genomic instability tend to be influenced by TP53 dysregulation. We illustrate how uncertainty in mutational signature recognition and project to samples impacts tumefaction category, reinforcing that making use of numerous orthogonal mutational signature information is not only advantageous, it is vital for accurate cyst stratification. Eventually, we provide a reference web-based device for cancer and experimentally-generated mutational signatures, known as
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