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Contact with arsenic reduces sperm fertility, impairs fertilization, and causes swelling and genotoxicity through interfering with autophagy, epigenetics, ROS generation, downregulation of important necessary protein phrase, metabolite changes, and hampering several signaling cascades, particularly by the alteration of NF-ĸB path. This work attempts to give a clear concept in regards to the different facets of arsenic resulting in male reproductive complications, often resulting in sterility. The very first