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Air pollution has been linked to increased mortality and morbidity. The Program 4 of the Healthy Aging in Industrial Environment study investigates whether the health and wellbeing benefits of physical activity (PA) can be fully realized in individuals living in highly polluted environments. Herein, we introduce the behavioral, psychological and neuroimaging protocol of the study. This is a prospective cohort study of N = 1500 individuals aged 18-65 years comparing (1) individuals living in the highly polluted, industrial region surrou