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than BVDV-positive herds (Coef = -3.03 %, 95 % CI -6.54; 0.49, p = 0.09, and vaccination against BVDV tended to be protective against high CR (Coef = -6.26 %, 95 % CI -12.61; 0.09, p = 0.053 compared to infected herds). This study shows that Estonian large-scale dairy herds are endemically infected with several important cattle pathogens. Most of the studied pathogens influence longevity and culling rates, thus entailing health and economic consequences. Parent-child interaction is essential to promote adaptive emotional, cognitive, and