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We then utilized AFSCs outlines to dissect the roles of Activin A (Act A) and standard fibroblast growth element and reported that Act A alone was with the capacity of keeping self-renewal although not developmental possible in vivo. Finally, we established a novel experimental system, for which AFSCs were effortlessly changed into multipotent progenitor stem cells utilizing Act A and bone morphogenetic necessary protein 4 (known as as ABSCs). Significantly, these ABSCs contributed to neural mesodermal prog
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