https://www.selleckchem.com/pr....oducts/abr-238901.ht
It is defined as progressive daily shifts in sleep onset and wake times. It mainly affects sight-impaired persons, is relatively rare in sighted patients, and is difficult to treat, with no guidelines. We report a case of N24SWD in a sighted young man who complained of alternating severe insomnia and excessive sleepiness, with a sleep agenda and actigraphic data showing a daily delay of approximately 2 hours. A novel therapy by total sleep deprivation followed by a combination of morning light therapy and nocturnal melatonin administ
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