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Exercise is recognized as a natural device of EV manufacturing taking part in preventive medicine. Specific interest is dedicated to describe the effect of EVs in cardioprotection after ischemia/reperfusion damage. Despair is a serious mental illness with a high prevalence in people, and neurobiology modifications of despair aren't fully clarified however. The present study aimed to investigate the antidepressant impact and underlying method of RP in behavioral despair mice and chronic discipline stress (CRS)-i