https://www.selleckchem.com/pr....oducts/kenpaullone.h
This is an emerging and promising field but this approach is actually little developed. We finally provide a section with a general conclusion and perspectives.Herein, we report a novel methodology to access N-aryl proline derivatives using amino-tethered α-diazoesters and cheap, readily available iron salts. Mechanistically, the aminocyclization reaction involves the initial formation of an iron-carbene complex followed by a nucleophilic attack of the aniline nitrogen atom to give an ammonium ylide intermediate, which finally under
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