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The sensitising effect of ORI on FLC in the treatment of C. albicans also included the promotion of apoptosis. We demonstrated that combining azoles with ORI exerted potent synergism and that ORI could promote sensitisation to azoles in azole-resistantC. albicans. The discovery that ORI can effectively inhibit drug efflux and promote apoptosis may provide new insights and therapeutic strategies to overcome increasing azole resistance in C. albicans. We demonstrated that combining azoles with ORI exerted potent synergism and that ORI co