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We found that PwD participated in more medical-related (Cliff's Delta = 0.71, 95% CI 0.34-1) and fewer sport-related (Cliff's Delta = -0.78, 95% CI -1 to -0.32) activities compared to the cognitively intact CTLs. Our results also suggested that longer duration of daily walking time (Cliff's Delta = 0.71, 95% CI 0.148-1) and longer outdoor activities at night, after 8 p.m. (Hedges' g = 1.42, 95% CI 0.85-1.09), are associated with cognitively intact individuals. Based on the proposed framework incorporating 12 GPS-based indicators, we