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ADHD Medications - Stimulant Or Non Stimulant? Stimulant medication is the first choice for ADHD treatment, since they're the most researched and have a fast-acting effect. However, they're not for everyone. These medications increase signaling between brain regions and nerves to decrease ADHD symptoms. These medications can also trigger side-effects like a change in heart rate or blood pressure as well as a loss of appetite. Stimulants Stimulants are among the most commonly used drugs used to treat ADHD. They are known for enhancing the a