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It is crucial but challenging to promote sluggish kinetics of oxygen evolution reaction (OER) for water splitting via finely tuning the hierarchical nanoarchitecture and electronic structure of the catalyst. To address such issues, herein we present iron-doped Ni3Se4/NiSe2 heterostructure-embedded metal-organic framework-derived mesoporous tubes (Ni-MOF-Fe-Se-40 realized by an interfacial engineering strategy. Due to the hierarchical nanoarchitecture of conductive two-dimensional nanosheet-constructed MOF-derived mesoporous tubes, co