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In this work, we first demonstrate the reliability of our method to then provide a relevant application case of our tool early development of D. melanogaster. Fly T-WEoN together with its step-by-step guide is available at https//weon.readthedocs.io.Breast cancer is a complex, heterogeneous disease at the phenotypic and molecular level. In particular, the transcriptional regulatory programs are known to be significantly affected and such transcriptional alterations are able to capture some of the heterogeneity of the disease, leading to