https://www.selleckchem.com/pr....oducts/epz015666.htm
All 23 controls matching demographic criteria were included. Among biopsied juvenile FM patients, 53% (8/15) had END 5th centile vs 4% (1/23) of healthy controls ( 0.001). Mean patient END was 273/mm skin surface (95% CI 198-389) vs 413/mm (95% CI 359-467, 0.001). As expected, patients with FM reported more functional disability, dysautonomia, and pain than healthy controls. Abnormal END reduction is common in adolescents with FM, with similar prevalence in adults with FM. More studies are needed to fully characterize t
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