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In addition, oral administration of orientin suppressed the IgE-mediated PCA reactions in a dose-dependent manner, which was evidenced by reduced Evan's blue pigmentation and ear swelling. CONCLUSIONS Based on these findings, we suggest that orientin might have potential to alleviate allergic reaction and mast cell-mediated allergic disease.BACKGROUND Prostate cancer (PCa) is the most common malignancy in men and in the absence of any effective treatments available. METHODS For the development of potential anticancer agents, 24 kinds o