https://www.selleckchem.com/pr....oducts/epoxomicin-bu
Our model shows that, first, without ACh receptors, Glu excitation of VTA DA and GABA neurons remains balanced and GABA inhibition cancels the direct excitation. Second, re-expression of ACh receptors on DA neurons provides an input that impedes membrane repolarization and is ineffective in restoring firing of DA neurons. Third, the distinct responses to ACh and nicotine occur because of distinct temporal patterns of these inputs pulsatile versus continuous. Altogether, this study highlights how β2-nAChRs influence coactivat
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