https://www.selleckchem.com/pr....oducts/emd638683.htm
Treating multiple brain metastases with a single isocenter improves efficiency but requires margins to account for rotation induced shifts that increase with target-to-isocenter distance. A method to select the single isocenter position that minimizes the total volume of normal tissue treated during multi-target stereotactic radiosurgery (SRS) is presented. A statistical framework was developed to quantify the impact of uncertainties on planning target volumes (PTV). Translational and rotational shifts were modeled with independent, z
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