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In addition, neutrophil infiltration into skin lesions triggered vascular remodeling including cutaneous vasodilation and improved vascular permeability in vivo plus in vitro. Microarray gene profile information showed that matrix metallopeptidase (MMP)-9 ended up being overexpressed in psoriatic neutrophils, and zymography assay further validated the bioactivity of MMP-9 released by psoriatic neutrophils. Moreover, MMP-9 activated vascular