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Furthermore, we find a high enhancement factor (∼1.42 × 108) for the substrate consisting of dense, small and uniformly sized pyramids. Finite Difference Time Domain (FDTD) simulations done on similar structures corroborate our results. Additionally, universal applicability of the proposed substrate is also verified by detecting methylene blue and methyl parathion analyte molecules. These substrates are much cheaper (∼5 USD for 1 × 1 cm2) in comparison with commercially available Klarite SERS substrates (∼100 USD for 2 × 2 mm2). We bel