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In this protocol, Finn chambers are widely used to localize the imiquimod cream to a small area of the skin. This leads to creation of serious and reproducible psoriatic epidermis reactions with even less imiquimod, significantly decreasing the probability of untoward systemic impacts. Moreover, having psoriasiform and control skin places for a passing fancy mice decreases inter-animal distinctions. The protocol can be readily adapted for any other skin condition designs concerning topical ap