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To deal with this, we created worldwide TSPO knockout (TSPO-KO) and neuronal TSPO transgenic (TSPO-Tg) mouse designs to research TSPO function within the legislation of anxiety- and depression-related actions using increased plus maze and forced swim test paradigms. Neuroactive steroid hormones had been measured into the brain by large-scale spectrometry. In vivo TSPO ligand pharmacokinetics was investigated using competitive dog