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22 and 36.23 μg mL-1, respectively. We found that the viability of SW480 cells was significantly lower than the HEK293 cells in all exposure concentrations of ZIF-8 NPs except control. Exposure of both cells resulted in increasing of the intracellular reactive oxygen species (ROS) production and activation of apoptosis pathway. The apoptosis rate of cancer SW480 cells was higher than the normal HEK293 cells. These findings indicate that synthetized ZIF-8 NPs could be a candidate for cancer therapy, although their toxic effects on the nor