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665 (95%CI 1.110~2.495, p=0.014). High-level necrosis component and lymphocytes component tend to be correlated with poor PFI, with a hazard ratio of 1.552 (95%CI 0.943~2.554, p=0.084) and 1.512 (95%CI 0.979~2.336, p=0.062), respectively. The result reveals the complex role of the tumor microenvironment in colon adenocarcinoma, and the quantified descriptors are potential predictors of disease progression. The method could be considered for risk stratification and targeted therapy and extend to other types of cancer, leading to a better u