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The in vitro cytotoxicity after exposing the A549 human lung cancer cells to the optimized Gef-StNPs ended up being found become higher than that of the pure Gef (IC50 = 6.037 ± 0.24 and 21.65 ± 0.32 μg/mL, correspondingly). The enhanced Gef-StNPs formula revealed superiority on the pure Gef in connection with mobile uptake in A549 personal mobile line (3.976 ± 0.14 and 1.777 ± 0.1 μg/mL) and apoptotic population (77.14 ± 1.43 and 29.38 ± 1.11 %), respectively. The outcomes elucidate why scien