https://www.selleckchem.com/pr....oducts/Cisplatin.htm
The cardiac function of rats was improved after SIRT3-overexpressed O-hMSCs transplantation. The infarct size, collagen content and expression levels of matrix metalloproteinase 2 (MMP2) and MMP9 decreased. Besides, the protein level of vascular endothelial growth factor A and vascular density increased after cell transplantation with SIRT3-modified O-hMSCs. These results indicate that damage resistance of hMSCs decline with age and SIRT3 might protect O-hMSCs against oxidative damage by activating CAT and MnSOD via transferring FOXO3
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