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ations. Future research should determine which strategies enhance the effectiveness of serious games, possibly by incorporating behavior change techniques. ©Daniël Bossen, Aline Broekema, Bart Visser, Annette Brons, Annieck Timmerman, Faridi van Etten-Jamaludin, Katja Braam, Raoul Engelbert. Originally published in the Journal of Medical Internet Research (http//www.jmir.org), 01.04.2020.BACKGROUND The comprehensive safety data of vaccine from post-licensure surveillance, especially the active surveillance, could guide administrations and individuals to mak