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The polyphenol of HP possesses numerous health benefits, including being anti-oxidative, anti-inflammatory, anticancer, antiproliferative, and other qualities. This study provides a method through which to obtain insight into the effects of HAD on polyphenols in food, and indicates potential targets to increase the polyphenol content in HP. © 2020 Wiley Periodicals, Inc.Accurately discriminating changes in clearance (CL ) from changes in bioavailability (F ) following an oral drug-drug interaction is difficult without carrying out an IV
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