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ctive on the real impact of PA. The goal of this article is to review data on the cardiovascular consequences of PA, in the context of an immature cardiovascular system, discuss the potential contribution of cardiovascular impairment on short and long-term outcomes, and propose further directions of research in this field. Copyright © 2020 Popescu, Panaitescu, Pavel, Zagrean, Peltecu and Zagrean.Introduction Neonatal HIE is associated with high morbidity and mortality. Current research, is focused on developing alte