https://abt702inhibitor.com/vo....lumetric-submission-
Sequential changes take place in different mobile compartments (dendritic, somatic, axonal) of these early-involved neurons. Tau pathology initially develops in distal segments of basal dendrites, then in proximal dendrites, the soma, and, eventually, when you look at the axon of affected pyramidal neurons. This series of unusual changes aids the concept that axons of cortico-cortical top-down neurons may carry and distribute unusual tau seeds in a focused manner (transsynaptical
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