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Folate is usually obtained through the food diet and folate deficiency is related to depression. Within the brain, folate is one nutrient amongst others involved in the creation of the neurotransmitters that affect state of mind. Studies involving folate supplementation for the treatment of depression have had mixed results but have omitted take into consideration the genetic polymorphisms, like the people in methyltetrahydrofolate reductase (MTHFR), that impact folate metabolism. Supplementation with
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