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Children of parents with mental health problems (CPM) have an increased risk for impaired health-related quality of life (HRQoL). This study aims at investigating the age- and gender-specific course of HRQoL and at exploring predictors of HRQoL in CPM based on longitudinal data (baseline, 1-year and 2-year follow-up) of a German population-based sample. Longitudinal data from the German BELLA study was analyzed (n = 1429; aged 11 to 17years at baseline). The SCL-S-9 in combination with the cutoff for the General Severity Index (GSI) from