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In conclusion, our findings indicate that CD147 is of vital importance for ALK+ ALCL to maintain the high energy demand of rapid cell proliferation, promoting lactate export, and tumor growth. Furthermore, CD147 has the potential to serve as a novel therapeutic target in ALK+ ALCL, and warrants further investigation.Several studies have reported that chronic myeloid leukaemia (CML) patients expressing e14a2 BCRABL1 have a faster molecular response to therapy compared to patients expressing e13a2. To explore the reason for this difference
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