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Cost to grain price ratios (CP) were 1.29, 1.65, and 1.65 for N, P, and K, respectively. The EORN had been 61 kg ha-1, 32% not as much as the recommended 90 kg N ha-1 for maize production within the semi-deciduous woodland zone of Ghana. Nitrogen application had the lowest CP ratio, making its application financially lucrative than P and K. The findings declare that the use of N at 61 kg N ha-1 to maize is economically profitable than at greater application prices. However, further studies