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During rollout of coronavirus disease vaccination, policymakers have faced critical trade-offs. Using a mathematical model of transmission, we found that timing of vaccination rollout would be expected to have a substantially greater effect on mortality rate than risk-based prioritization and uptake and that prioritizing first doses over second doses may be lifesaving.The coronavirus disease (COVID-19) pandemic might affect tuberculosis (T diagnosis and patient care. We analyzed a citywide electronic TB register in Blantyre, Malawi and