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, MTX osteopathy). We now have retrospectively analyzed information from 34 clients with MTX therapy, serious lower extremity discomfort and immobilization. MRI scans, bone turnover markers, bone tissue mineral thickness (DXA) and bone microarchitecture (HR-pQCT) were assessed. Stress fractures had been also imaged with cone ray CT. Although the time passed between medical beginning and analysis ended up being prolonged (17.4 ± 8.6 months), the stress fractures had a pathognomonic appearance (