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Numerous chromatography methods have been published for estimation of fixed-dose combinations (FDC) products of aspirin and ramipril with other drugs. But no published report has been found which promotes simultaneous estimation of some FDC of aspirin and ramipril with other drugs using a single chromatography condition. Hence, the development of the HPTLC method was performed for simultaneous estimation of FDC of aspirin and ramipril with drugs understudy to save cost, time and solvent for analysis using risk and DoE-based AQbD approac