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Many asymptomatic individuals had homoplasmic or near homoplasmic levels of the m.3250TC variant, suggesting the penetrance is incomplete. Patient-derived fibroblasts demonstrated lowered ATP production and increased levels of reactive oxygen species. Our results demonstrate that the m.3250TC variant exhibits incomplete penetrance and may be a possible cause of cardiomyopathy by impacting cellular respiration in mitochondria.There are no studies which have compared the risk of severe COVID-19 and related mortality between transpla