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These technical advances enable guinea pigs to once again subscribe to our knowledge of SFR. Importantly, going back to the guinea pig model with improved tools will enable rickettsial researchers to validate and potentially refine outcomes acquired utilizing mice. This minireview summarizes Cavia porcellus as an animal model for person tick-borne rickettsial diseases.Ticks, like Ixodes ricinus, have bad effects on human and animal health in Germany and worldwide, with almost no spec