https://www.selleckchem.com/pr....oducts/LDE225(NVP-LD
Premorbid metformin exposure was not significantly associated with initial lactate levels (mean difference, 0.39 [-0.50 to 1.28]; i 2 = 72%; p = 0.39). Conclusions The meta-analysis suggests that premorbid metformin exposure is associated with decreased mortality in sepsis but not with hyperlactatemia. What are the potential mechanisms and whether there is any effect on organ dysfunction remain unclear. Copyright (c) 2019 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine.