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Dogs are natural reservoir of Chagas disease (CD) and Leishmaniasis and have been used for studies of these infections as they develop different clinical forms of these diseases similar to humans. This revision describes publications in dog model relative to CD and Leishmaniasis chemotherapy. The search of articles was based in PubMed, Scopus and MESH using the keywords dog, Trypanosoma cruzi, treatment (T. cruzi chemotherapy analysis) in addition to dog, Leishmania chagasi, Leishmania infantum, canine visceral leishmaniasis, treatment (Leishmania chemother
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