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Repeated usage of both 2000 mg of PO and IV glutathione was effective in further relieving respiratory symptoms. Conclusion Oral and IV glutathione, glutathione precursors (N-acetyl-cysteine) and alpha lipoic acid may express a novel treatment approach for blocking NFKappaB and handling "cytokine storm syndrome" and breathing stress in patients with COVID-19 pneumonia. © 2020 The Authors. Posted by Elsevier Ltd.Objective the purpose of this research was to assess the